NEURO360-aligned research led by Rohit V. Pappu, PhD, with Min Kyung Shinn, PhD, at WashU’s McKelvey School of Engineering is uncovering new therapeutic targets for neurodegenerative disorders such as ALS. Their work reveals that key nuclear speckle proteins form precisely organized “microphases” that may drive disease-related RNA splicing errors, offering new opportunities to disrupt or stabilize these structures to slow disease progression.

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